A clinical study with elite cyclists found that a supplement containing oleuropein, B-vitamins, and magnesium significantly improved performance and reduced fatigue. The supplement led to a 25% increase in maximal power output and a 16% boost in perceived performance. Furthermore, athletes who took the supplement experienced 38% less fatigue during high-intensity training.

This study demonstrates that supplementing with olive leaf extract (OLE) can enhance the body's response to moderate-intensity continuous exercise. It achieves this by improving skeletal muscle function, specifically by activating pyruvate dehydrogenase (PDH) and influencing genes related to mitochondrial and inflammatory responses.

This study investigated how an oleuropein-enriched olive leaf extract supplement affects the metabolism of healthy young male athletes. Researchers found that taking the supplement for one week influenced specific metabolic pathways, particularly those related to tryptophan and acylcarnitines. The results suggest that the supplement may enhance serotonin turnover and improve performance, in addition to potentially altering the body’s lipid profile and antioxidant status.

This study discovered that oleuropein, a natural compound from olives, can activate mitochondrial calcium uptake, a process that is often impaired during aging. By doing so, it improves energy metabolism in muscle cells. This leads to enhanced endurance and muscle performance in both young and aged mice